Apoptosis at the optic fissure shapes transient retinal myeloid states
Microglia and CNS-associated macrophages (CAMs) originate from yolk sac erythromyeloid progenitors, yet the process that mediates their colonization of the mammalian eye and the developmental cues that promote their diversification remain unclear. Here, we identify the optic fissure as the primary entry site for myeloid cells into the embryonic mouse retina. This entry is spatially and temporally…
Researchers have identified the optic fissure as the primary entry point for myeloid cells into the embryonic mouse retina. This entry coincides with a localized wave of cellular death, creating an apoptotic niche. The optic fissure's role in this process has implications for the early development of retinal myeloid cells.
Written by urgent.news from bioRxiv's reporting — not their text. Machine-written — may contain errors; check the original before relying on it.
