Anisomycin-induced ribosome collisions follow a dose-dependent positional rule, distinct from the UV-induced collision landscape
Ribosome collisions trigger stress pathways such as the ribotoxic stress response (RSR), yet how different ribosome-impairing stimuli shape where collisions form on mRNAs remains unclear. Here, we combine monosome- and disome-resolved ribosome profiling with proteomics of collided-ribosome fractions to compare anisomycin- and UV-induced ribosome impairment in mouse embryonic stem cells. Low-dose…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
