AAV-Mediated Ribozyme Targeting of HSV-1 Latency-Associated Transcript RNAs Reveals Distinct Functions of the LAT Intron and Exon In Vivo
Herpes Simplex Virus 1 (HSV-1) establishes lifelong latency in sensory neurons of the trigeminal ganglia (TG), from which periodic reactivation causes recurrent disease. The latency-associated transcript (LAT) has been implicated in latency establishment, neuronal survival, and reactivation; however, most functional studies have relied on viral deletion mutants that alter genomic architecture and…
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