ZFP36 is a post-transcriptional regulator of the P2X4 receptor in myeloid cells
P2X4 is an ATP-gated purinergic receptor upregulated in spinal microglia after peripheral nerve injury, where it plays a key role in neuropathic pain. Yet, the molecular mechanisms controlling P2X4 expression remain incompletely understood. To address this question, we examined P2X4 mRNA expression and translation in spinal microglia following nerve injury. While total P2X4 mRNA levels remained…
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