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Deep-learning-driven tumor microenvironment profiling improves immunotherapy response prediction

Immunotherapy has transformed the management of many cancers, such as clear cell renal cell carcinoma (ccRCC), yet durable clinical benefit is achieved in only a subset of patients. Immunotherapy outcomes are governed by the multicellular tumor microenvironment (TME), through the structured and directional interplay of regulatory programs and ligand-receptor communications. Yet most existing…

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