Cardiometabolic stress induces atrial myopathy in mice, characterized by structural remodelling, metabolic dysfunction, and incomplete transcriptional recovery.
Background: The mechanisms underlying atrial remodelling and recovery following the withdrawal of cardiometabolic stress remain incompletely understood. We investigated the functional, metabolic, and transcriptional consequences of metabolic-hypertensive stress (MHS), a murine model of cardiometabolic HFpEF, in the left atrium (LA) and assessed the reversibility of these alterations following…
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