NFL Monday Night Football best bets Week 5

The Buffalo Bills and Los Angeles Rams face off in a high-profile Monday Night Football game. The Bills, who lead the NFL in scoring at 31.8 points per game, will be looking to maintain their offensive momentum against the Rams. The Rams boast an explosive running back in Kyren Williams, who averages 5.4 yards per carry and has already accumulated 294 rushing yards this season.

Williams' versatility as a runner and receiver makes him an attractive target for props. Another key player to watch is Buffalo's wide receiver Khalil Shakir, who only needs four receptions to cash in on the prop bet. With the Bills averaging 31.8 points per game, there should be plenty of opportunities for him to make an impact.

Quarterback Matthew Stafford of the Rams has already thrown for 1,189 yards and six touchdowns, making him a prime candidate to hit the 1.5 touchdown pass prop. Buffalo's running back James Cook III, with 421 rushing yards on 70 carries, presents another attractive opportunity for props. With Buffalo's offense capable of creating a fast-paced game, it's likely that Cook will continue to be a key contributor, making his 79.5 rush + receiving yards prop a strong bet.