Diacylglycerol Kinases Balance DAG Signaling to Control B Cell Maturation, Germinal Center Homeostasis, and Humoral Immunity
Diacylglycerol (DAG) is a critical second messenger downstream of the B-cell receptor (BCR), but how DAG signaling is regulated during B-cell development and humoral responses remains incompletely understood. Here, complementary gain- and loss-of-function approaches revealed stage-specific requirements for diacylglycerol kinase (DGK)-regulated signaling in B cells. Expression of the…
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