Intragenic epistasis in couch potato shapes life history traits and climatic adaptation in Drosophila melanogaster
Populations adapting to heterogeneous environments often harbor many alleles that covary with environmental gradients, yet how so many adaptive variants can be maintained and show signatures of local adaptation remains unclear. Epistatic non-additive interactions among alleles may concentrate fitness effects at specific allelic combinations to shape complex traits and facilitate adaptation. We…
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