Eagles Week 5 fantasy football injury report vs. Jaguars: DeVonta Smith injury is bad news for floundering offense

The Philadelphia Eagles enter Week 5 of the 2026 NFL season with a slew of injuries that could significantly impact their fantasy football lineup. The team has 15 players on the injury report, with eight either out or questionable for the upcoming game against the Jacksonville Jaguars.

Saquon Barkley, the Eagles' star running back, and Tank Bigsby, his primary backup, are both out due to injury, leaving the running back position in a precarious state. Will Shipley, a rookie, and Dameon Pierce are the primary backups, but both have limited experience and may not be reliable options for fantasy managers.

At wide receiver and tight end, the Eagles face an even more daunting situation. Makai Lemon remains the only guaranteed starter, but he will be joined by Dontayvion Wicks, who has a hamstring injury, Dallas Goedert, who is questionable, and Hollywood Brown, who is out with an ankle injury. Evan Engram, Jim Brown, and Jalen Hurts are all injured and unavailable to play.

From a fantasy football perspective, the Eagles' injury situation creates a significant challenge. Managers looking for reliable production from the Eagles may find themselves with slim pickings. However, if Dallas Goedert is available to play, he could be a valuable option, as he has proven to be a reliable target for quarterback Jalen Hurts.