CHORUS: A proteome-scale atlas of membrane interaction interfaces constructed using cross-protein language model embeddings from sequences alone
Membrane proteins drive vital cellular signaling and bioenergetics yet resolving their physical interaction interfaces remains hindered by the paucity of experimental complexes and the breakdown of sequence alignments across hydrophobic bilayers. Here, we present CHORUS, a sequence-only deep-learning framework that decodes interaction sites across membrane proteins without requiring 3D…
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