Coronavirus nucleocapsid proteins differentially antagonize RIG-I-like receptor signaling to shape pathogenicity
Coronaviruses cause human infections with divergent clinical outcomes. Viral proteins likely play important roles in the severity of human diseases but are poorly defined. In this study, we discovered that viral nucleocapsid (N) proteins from various human coronaviruses have distinct abilities to antagonize human innate immune responses. N proteins from more pathogenic coronaviruses, such as…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
