Cardiomyocyte Perm1 sustains cardiac bioenergetic reserve and exercise capacity
Objective: Mitochondrial oxidative capacity in striated muscle is governed by the PGC-1/ERR transcriptional axis, which controls not only steady-state respiration but the capacity to expand energy production when demand rises. Whether this reserve function requires dedicated downstream effectors, and whether its loss is detectable at rest, remains unclear. We asked whether Perm1, a striated…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
