Ole Miss vs Vanderbilt Prediction: The Rebels' Road Back

Ole Miss and Vanderbilt are set to face off in a crucial SEC matchup on Saturday, October 10, 2026, at 3:30 PM ET, with a TV broadcast on ESPN. The game will take place at the FirstBank Stadium in Nashville, TN, as part of the Week 6 schedule and predictions. The latest consensus line has Ole Miss favored by 9.5 points, with a total of 54.5 points.

Ole Miss has shown strength of late, having won five consecutive games dating back to Vanderbilt's last victory in 2018. However, they must first secure a victory against Vanderbilt to stay in contention for the SEC title and another College Football Playoff appearance.

Vanderbilt's offense, led by freshman quarterback Jared Curtis (expected to return after a recent injury), will likely be a key factor in any potential upset. If Curtis is unable to perform at his best, veteran Blaze Berlowitz may step up to replace him. Vanderbilt's passing game could potentially trouble Ole Miss' defense, which struggled against both the Louisville passing attack and Florida's ground game.

Despite Vanderbilt's recent struggles, their offensive firepower could be enough to outpace Ole Miss' defense and keep the Rebels off-balance. The Rebels, on the other hand, possess a potent passing game that could open up the field for their offense and force Vanderbilt to push their offense into more challenging situations. With a solid ground game and successful recent play, Ole Miss appears to be the favorite for this matchup.