Adjustable nanosensors turn water pressure into fluorescent signals, with stiffness shaping sensitivity
A novel nanovesicle-based platform developed at Institute of Science Tokyo can measure hydrostatic pressure by converting pressure-induced molecular changes into fluorescence signals.
Researchers from the Institute of Science Tokyo have developed a nanovesicle-based platform for measuring hydrostatic pressure by converting pressure-induced molecular changes into fluorescent signals. The novel platform, called Pyr-PICsomes, comprises pyrene-modified polyionic complex vesicles whose membrane stiffness can be adjusted to regulate their pressure sensitivity.
Soft vesicles exhibit strong sensitivity in the 0.1–50 MPa range, while stiffer vesicles show pressure-dependent changes in fluorescence lifetime. This versatile sensing method could enable the investigation of hydrostatic pressure-dependent phenomena in diverse inaccessible environments, such as the deep ocean and living tissues, where traditional molecular sensors often struggle.
Brief written by urgent.news from Phys.org's own syndicated text. Machine-written — may contain errors; check the original before relying on it.
