Modulation of gp130 Cytokine Receptor Family by Herpes Simplex Virus 1 as a Strategy for Immune Evasion?
HSV-1 is a neurotropic human pathogen that establishes lifelong latency in sensory neurons. Periodic reactivation causes mucocutaneous lesions and, in some cases, severe corneal and neurological disease. While HSV-1 utilizes numerous viral proteins to extensively reprogram host signaling pathways and evade antiviral responses, how it alters host cytokine receptor networks remains poorly…
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