Connectomics by Sequencing Reveals Self-Organizing Principles of Neuronal Networks in Cerebral Organoids
Functional neural networks emerge as developing neurons form synaptic connections. Revealing how these connections are organized and perturbed in disease requires linking single-neuron connectivity to molecular state across thousands of networks, which is challenging with current methods. We developed COSCO (Connectomics by Sequencing in Cerebral Organoids), combining barcoded monosynaptic rabies…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
