Additive-input encoding fails operator-level target-held-out prediction on current Perturb-seq screens
Pooled Perturb-seq screens are often interpreted through a linear steady-state model in which each targeted gene supplies an additive perturbation input. Although this formulation identifies an operator on the observed response subspace in closed form, identifiability alone does not establish that inferred operators generalize to new perturbation targets. We evaluated fixed program-space additive…
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