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A sunflower FLS2 guides reconstruction of recognition of a Xanthomonas flg22 escape variant across divergent FLS2 receptors

FLS2-mediated perception of the bacterial flagellin epitope flg22 is frequently compromised by pathogen sequence variation, and Val14-containing Xanthomonas flg22 variants remain unrecognized by multiple characterized expanded-recognition FLS2 homologues. Using AlphaFold 3-based structural screening of 256 natural FLS2 homologues against the flg22 epitope from Xanthomonas campestris pv.…

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