Bills at Rams: 5 storylines to watch for ahead of Week 5

Bills Wire presents five storylines to watch for ahead of Sunday's Week 5 matchup between the Buffalo Bills and the Los Angeles Rams at SoFi Stadium.

1. Pressure has shifted in a hurry. While the Rams have been the focus of national attention following their comeback win against the Philadelphia Eagles in Week 4, the Bills are now the primary story. The team will be asked to bounce back after their recent loss to the New England Patriots.

2. The Bills are playing a prime-time game for the first time this season. This is a first for the Bills, who will be traveling across the country for the highly anticipated Thursday Night Football matchup. These circumstances are expected to be discussed in the days leading up to the game.

3. The secondary issues are significant. The Bills' defensive secondary, particularly after injuries to Christian Benford (foot) and Max Hairston, will need to improve against the Rams' star quarterback Matthew Stafford and star wide receivers Puka Nacua and Davante Adams.

4. Injuries last week affected both teams. The Bills lost players DJ Moore (shoulder), Ed Oliver (knee), and Dee Alford (ankle) to injuries in their last game. The Rams also suffered losses, though the specific players have not been mentioned.

5. After Josh Allen's poor performance in the Patriots game, he is no longer the 2026 NFL MVP favorite. The Bills quarterback will be under scrutiny ahead of the match, as he prepares to discuss his plans for improvement.