Tyrosine phosphorylation unfolds nucleophosmin and disrupts its integration into the nucleolus

Proceedings of the National Academy of Sciences, Volume 123, Issue 41, October 2026. SignificanceNucleophosmin (NPM1) preserves nucleolar architecture and cellular homeostasis, yet how phosphorylation modulates its structure and function has remained unclear. We characterize a set of stress-induced tyrosine phosphorylations that ...

pnas.org ·10d ago

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