Opposing activity of SOX9 and Wnt in the developing otocyst ensures SOX10 control of endolymphatic development

Proceedings of the National Academy of Sciences, Volume 123, Issue 41, October 2026. SignificanceThis study suggests a conserved SOX9–Wnt–SOX10 circuit directing inner ear endolymphatic cell fate, essential for hearing and balance. Using mouse genetics and human organoids to study the deafness-causingSOX9Y440X/+mutation, we reveal ...

pnas.org ·10d ago

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