AA: Pulmonary aspiration, regurgitation under anesthesia more likely with GLP-1 RAs
In the United Kingdom, 2.9% of patients undergoing anesthesia reported receiving glucagon-like peptide-1 receptor agonists (GLP-1 RAs), according to a study published online Sept. 16 in Anaesthesia to coincide with the annual meeting of the Association of Anaesthetists, held Sept. 16–18 in Liverpool, England.
A study in the UK found that 2.9% of patients undergoing anesthesia were receiving glucagon-like peptide-1 receptor agonists (GLP-1 RAs). The research, conducted by Thomas E. Potter and colleagues at Guy's and St Thomas' NHS Foundation Trust in London, analyzed 47,039 adults undergoing elective or emergency procedures. The incidence of pulmonary aspiration and/or regurgitation was 0.12% among patients not taking GLP-1 RAs and 1.41% among those taking the drugs (odds ratio, 11.39).
The study observed that these complications were most common during emergence from anesthesia among GLP-1 RA users. The authors suggest that further prospective studies are needed to explore interventions that might reduce the risks associated with pulmonary aspiration and improve patient outcomes following GLP-1 RA use during anesthesia.
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