4 matchups to watch when Broncos face 49ers in Week 4

As the Denver Broncos prepare to face the San Francisco 49ers in Week 4, several key matchups will determine the outcome of the game. First and foremost, the Broncos will need to secure a victory for the first time against the 49ers this season. After last year's road success against the 49ers, where they rushed for 201 yards, Denver will aim to replicate that success, possibly through a ground game.

However, they may have to find an alternate route to victory if that strategy doesn't work out. Here's a breakdown of the critical matchups to watch:

Que Robinson and the Broncos' pass rush will face a formidable challenge from San Francisco's line, particularly Trent Williams, one of the best left tackles in the league. Although Bonitto, the Broncos' pass rusher, is talented, Williams presents a tougher challenge. On the other side of the field, Robinson could significantly impact the game. The Broncos need him to disrupt the 49ers' backfield and disrupt Brock Purdy's rhythm, even if it doesn't result in sacks, as it could slow down the offensive attack.

Jaylen Waddle is a crucial player for the Broncos, and their overall performance improves significantly when he makes plays. In the two games this season, he has been held to two catches or less, but in the game against the Jacksonville Jaguars, he delivered a standout performance, catching eight passes for 138 yards. The Broncos must get Waddle involved early and often and take advantage of the potential matchup with cornerback Renardo Green to yield positive results. Waddle's involvement could be a game-changer for the Broncos.

The 49ers' tight end, George Kittle, is a significant threat to the Broncos' defense, especially inside linebackers Alex Singleton and Justin Strnad. To contain Kittle, the Broncos will rely on former 49ers safety Talanoa Hufanga and cornerback Brandon Jones. Kittle's ability to score three touchdowns in the last two weeks makes him a crucial offensive player for the 49ers, and the Broncos must stay vigilant in keeping him in check.

Finally, Ja Quan McMillian's matchup against Brandin Cooks could be a deciding factor in the game. In last year's playoff game against the Buffalo Bills, McMillian intercepted a pass from Brandin Cooks, helping the Broncos reach the AFC Championship Game. Cooks recently signed with the 49ers practice squad, and he will be elevated for this game due to the team's injuries at the position, notably to Mike Evans, who is questionable. McMillian needs to put on a stellar performance to secure a victory for the Broncos.