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ST-DISTAL: Dual-Branch Graph Convolution with Distributional Alignment for Cell-Type Deconvolution

Spatial transcriptomics enables high-throughput gene expression profiling while preserving spatial information, offering valuable insights into tissue architecture and cellular organization. Methods that achieve single-cell or subcellular spatial resolution typically rely on predefined gene panels, which limits genome-wide discovery. In contrast, sequencing-based spatial transcriptomics platforms…

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Proteomics Maps Eye-Infecting Acanthamoeba Mitochondria Across Oxygen Levels

A new catalog of 1,122 mitochondrial proteins reveals how Acanthamoeba adapts to oxygen loss—and may highlight possible targets for treating sight-threatening infections.

  • Acanthamoeba mitochondria adapt to low oxygen by producing hydrogen gas
  • Researchers map 1,122 proteins, 381 unique to Acanthamoeba
  • Study in Cell improves understanding of amoeba's metabolic flexibility

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