Serum IgM crosslinks hepatitis B subviral particles into supramolecular immune complexes
Hepatitis B virus (HBV)-infected cells release hepatitis B surface antigen (HBsAg)-rich subviral particles (SVPs) in large excess over infectious virions. SVPs bind antibodies against HBsAg (anti-HBs), including neutralizing antibodies, but the physical products of antibody capture in human blood are uncharacterized. Here we used cryo-electron tomography (cryo-ET) to image HBsAg-enriched serum…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
