Post-transcriptional dysregulation precedes morphological transformation in chemically induced liver cancer
DNA lesions impede RNA polymerase II, yet the transcriptional consequences of that stress are less understood than the lesions themselves. We reanalysed total RNA and matched whole genomes from 438 liver lesions across four divergent mouse backgrounds, one of them the separate species M. caroli, 428 of them induced by a single dose of diethylnitrosamine (DEN) and 10 arising spontaneously,…
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