Clonally expanded CD8 T cells in AML adopt an NK-like program distinct from canonical exhaustion

CD8 T cells are key mediators of anti-tumor immunity, yet their differentiation states and clonal architecture within the acute myeloid leukemia (AML) bone marrow microenvironment remain incompletely defined. We performed high dimensional immune profiling of bone marrow samples from 46 newly diagnosed AML patients using mass cytometry to probe the microenvironment and T cell states. We used…

biorxiv.org ·10h ago

We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.

Read the original at biorxiv.org →

More in Science

Counteranions reshape molecular packing to tune magnetism in copper complexes

Magnetic properties in molecular materials depend not only on the molecular components themselves but also on their solid-state organization.

10h ago ·phys.org

Our Project Suncatcher prototype satellite is in orbit.

Google's prototype satellite for Project Suncatcher, built in partnership with Planet, launched into orbit aboard the Transporter-18 rideshare mission with SpaceX.

10h ago ·blog.google

Mangroves keep waves at bay. A new study helps scientists predict how

Existing at the junction of land and sea, mangrove forests have long been heralded for their ecosystem services, including their ability to buffer coastal areas against storm surges and rising seas.

10h ago ·news.mongabay.com

Physicists Find a Superconductor That 'Breaks' The Symmetry of Time – A First For Its Kind

(sakkmesterke/iStock/Getty Images Plus) What is happening? Don't miss a story, subscribe here.

9h ago ·sciencealert.com

Proteomics Maps Eye-Infecting Acanthamoeba Mitochondria Across Oxygen Levels

A new catalog of 1,122 mitochondrial proteins reveals how Acanthamoeba adapts to oxygen loss—and may highlight possible targets for treating sight-threatening infections.

Acanthamoeba mitochondria adapt to low oxygen by producing hydrogen gas
Researchers map 1,122 proteins, 381 unique to Acanthamoeba
Study in Cell improves understanding of amoeba's metabolic flexibility

9h ago ·genengnews.com

SpaceX flight led by first Black female commander sets US speed record

Four astronauts pulled up at International Space Station after eight-hour express flight led by Jessica Watkins Four astronauts pulled up at the International Space Station on Thursday after launching…

9h ago ·theguardian.com