BrightEyes-Scope: A Reference Implementation for Image Scanning Microscopy with SPAD Array Detection

Image scanning microscopy (ISM) is emerging as the natural evolution of confocal laser-scanning microscopy, combining optical sectioning and a two-fold improvement in lateral resolution with high signal-to-noise ratio. Single-photon avalanche diode (SPAD) array detectors enable an effective implementation of ISM by recording a micro-image at each scan position with single-photon sensitivity,…

biorxiv.org ·10h ago

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