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Preclinical evaluation of the biodistribution, safety, and hemocompatibility of PEG-coated iron oxide magnetic nanoparticles in a viral oncogenesis mouse model

Previously, we demonstrated the biosafety of polyethylene glycol-coated iron oxide nanoparticles (MAG@PEG) in a cellular model of viral oncogenesis, supporting their further preclinical evaluation. Herein, we evaluated the safety and biodistribution of MAG@PEG in tumor-bearing mice and assessed the influence of an external magnetic field on nanoparticle distribution. Animals were randomly…

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