Fold'EM: Direct atomic structure inference from Cryo-EM particles
Single-particle cryo-electron microscopy (cryo-EM) has become a widely adopted technique for biomolecular structure determination. The conventional cryo-EM computational pipeline first combines many particle images to reconstruct an electrostatic potential (ESP) map and then fits an atomic model to the recovered map. Density reconstruction has high sample complexity, requiring large numbers of…
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