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Repurposing PeTriBERT for Protein Protein Interaction Prediction with Sequence Structure Fusion

Recent advances in artificial intelligence have enabled models to capture protein sequence and structural features. We present PeTriPPI2, a hybrid framework for protein--protein interaction (PPI) prediction that combines sequence embeddings from ESM-2 with structural representations from PeTriBERT, an encoder originally designed for inverse folding. We evaluate this sequence--structure approach…

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