Intravenous hyaluronidase-expressing oncolytic adenovirus with chemotherapy in metastatic pancreatic cancer: a randomized phase 2b trial
Nature Medicine, Published online: 30 September 2026; doi:10.1038/s41591-026-04705-y In the randomized phase 2b VIRAGE trial, patients with treatment-naive metastatic pancreatic cancer received the hyaluronidase-expressing oncolytic adenovirus zabilugene almadenorepvec (VCN-01) intravenously with gemcitabine and nab-paclitaxel (GnP) or GnP alone, showing that VCN-01 plus GnP led to prolonged…
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