Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation
Phospholipase C β (PLCβ) enzymes are activated by heterotrimeric G protein subunits, increasing hydrolysis of phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) at the plasma membrane. All four human PLCβ isoforms (PLCβ1–4) are activated by Gα q , whereas PLCβ1–3 are activated to varying extents by Gβγ. The binding sites for Gα q on PLCβ are well established, and much has been learned about its…
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