Elevated C-reactive protein linked to increased risk for incident heart failure, all-cause mortality
For adults with an increased cardiovascular risk, elevated C-reactive protein (CRP) levels are associated with an elevated risk of incident heart failure and all-cause mortality, according to a study recently published online in the International Journal of Cardiology.
Adults with at least two cardiovascular risk factors who have persistent high levels of C-reactive protein (CRP) are at a greater risk of developing heart failure and dying from any cause, according to a recent study published in the International Journal of Cardiology. Researchers from the Université de Lorraine in Nancy, France, analyzed data from 64,743 adults ages 40 to 80, who had available body mass index (BMI) data, at least two cardiovascular risk factors, and at least two consecutive CRP measurements within the same range.
Participants were divided into two groups based on their CRP levels: low (0.1 to 3.0 mg/L) or elevated (3.1 to 10.0 mg/L). After matching, each group consisted of 19,547 participants. The study found that elevated CRP levels were linked to an increased risk of incident heart failure (hazard ratio, 1.34), all-cause mortality (hazard ratio, 1.90), and a composite of both (hazard ratio, 1.49).
Similar associations were also observed in exploratory analyses for heart failure with reduced or preserved ejection fraction. The authors suggest that these findings highlight the prognostic relevance of persistent CRP elevation and call for further research into the relationship between low-grade inflammation and heart failure development.
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