Microplastics clog liver immune cells, driving fat buildup in mice
Microplastics appear capable of significantly impairing the function of phagocytes in the liver, at least in mice. In turn, this disrupts the metabolism of this vital organ and increases the build-up of fat inside it. These key findings from a joint German-Austrian study led by the University of Bonn, have now been published in the journal Nature Metabolism.
Microplastics have been found to interfere with the immune function of liver cells in mice, leading to increased fat accumulation. Scientists from the University of Bonn conducted a joint study, revealing that these tiny plastic particles accumulate in liver macrophages, disrupting their ability to break down foreign matter and pathogens.
The foreign plastic then blocks the macrophages' lysosomes, which are crucial for digesting and recycling cellular waste. In response, macrophages produce more apolipoproteins, proteins that transport fats, acting as a stress signal. This triggers liver cells to store more fat, resulting in metabolic imbalances. Interestingly, smaller nanoplastics seem to cause less disruption, instead accumulating in brown adipose tissue and stimulating heat production.
This research highlights the potential health risks posed by microplastics and suggests future investigations into their effects on human health.
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