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Scientists overcome key barrier to self-amplifying vaccines

Scientists at Queen Mary University of London have found a way to overcome cells' natural defenses against self-amplifying mRNA vaccines, allowing the cells to produce significantly more of the target protein. The findings are published in Nature Communications.

Scientists overcome key barrier to self-amplifying vaccines

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Viral Protein Helps Self-Amplifying RNA Overcome Cellular Defenses

Adding a viral protein, NoV B2, helped self-amplifying RNA overcome cellular defenses and produce more target protein without diminishing immune stimulation, potentially enabling future vaccines to…

  • Researchers add viral protein NoV B2 to saRNA vaccines
  • NoV B2 reduces cells' restriction of saRNA, boosting protein production
  • Breakthrough addresses key challenge for saRNA in gene therapies

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