AI-guided optimization for thermostable mRNA vaccines
Nature Biotechnology, Published online: 28 September 2026; doi:10.1038/s41587-026-03330-x AGENT, an AI-driven framework integrating high-throughput experimentation with Bayesian optimization, enables the rapid engineering of thermostable, solid-state mRNA vaccines. These formulations retained full bioactivity after storage at 37 °C for 2 months, elicited immune responses non-inferior to fresh…
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