LIVE Giants vs Titans score, updates, highlights as Jameis Winston starts

On Sunday, Sept. 27 at 1 p.m., the New York Giants will face the winless Tennessee Titans at MetLife Stadium. The Giants, under new head coach John Harbaugh, are hoping to turn around their season that began with promise but now feels like many others that led to the firing of four head coaches. The game takes on added significance as Harbaugh will be managing his team without starting quarterback Jameis Winston, who underwent surgery this week to repair damage to his MCL and meniscus, ruling him out for the remainder of the 2026 season.

This loss hits the Giants hard, especially considering their recent history. In the past, Harbaugh has dealt with similar injuries to quarterbacks in Baltimore and Baltimore, turning to other players to fill the role. The connection between the Giants and Titans runs deep, with many players and coaches from one team ending up on the other.

This includes Brian Daboll, who was fired as Giants head coach last season but is now the Titans' offensive coordinator. Other notable connections include former Giants players who have moved on to the Titans, and vice versa. The Titans' head coach Robert Saleh, who previously coached the Jets, is making a homecoming appearance.

This game, coined by NFL Network's Mike Garafolo as the "Sliding Doors Bowl," promises to be a significant one for both teams as Harbaugh's Giants look to avoid a repeat of their disappointing past.