49ers news: Nick Bosa-less San Francisco loses Trent Williams, another star defender during Cardinals game

The San Francisco 49ers faced a challenging Week 3 game against the Arizona Cardinals at Levi's Stadium, with linebacker Mike Evans suffering a concerning injury and star offensive tackle Trent Williams also sidelined. The 49ers, lacking their usual defensive anchor Nick Bosa, ultimately lost another star defender during the match.

Defensive back Deommodore Lenoir left the game after taking an accidental hit from his teammate Fred Warner, leading to an evaluation for a potential concussion. Williams suffered an apparent head injury during a play where Christian McCaffrey scored a touchdown, and he appeared slow to get up, leading with his helmet. The 49ers started strongly with a 80-yard touchdown from Evans in the first quarter, but the Cardinals managed to close the gap before halftime.

While the 49ers led in total yards early in the fourth quarter, Arizona managed to pull within three points near the end of the game thanks to a late touchdown pass from Brock Purdy to Jeremiyah Love. The injuries continued to mount for the 49ers, who have struggled with injury concerns in recent years, but the team's depth remains a positive factor as they aim for a Super Bowl run.