2026 Presidents Cup Sunday TV coverage: How to watch Day 4 at Medinah

The San Francisco 49ers are set to face the Arizona Cardinals in a crucial Week 3 matchup on Sunday, September 27, 2026, at Levi's Stadium in Santa Clara, CA. Kickoff is scheduled for 01:05 PM PST or 4:05 PM EST. Fox will broadcast the game, with Kevin Kugler serving as play-by-play announcer and Daryl Johnston providing color commentary.

The 49ers, who have shown impressive form through their first two games, will be without several key players due to injuries. Defensive end Nick Bosa is out with a calf muscle strain, while wide receiver Demarcus Robinson and defensive tackle James Thompson are also sidelined with ankle injuries. Quarterback Brock Purdy is questionable, and Mike Evans is listed as questionable due to a hip issue.

For the Cardinals, cornerback Will Johnson is on injured reserve with a neck injury, and quarterback Jacoby Brissett is listed as questionable due to a hip issue. Cornerback Garrett Williams, who suffered an Achilles tear last year, is expected to make his season debut.

The 49ers currently lead the division, with a chance to wrestle first place from the Seattle Seahawks. A victory against the Cardinals would solidify their position at the top of the division. However, the loss of key players for both teams adds an extra layer of significance to this matchup.