Mouse Neural Organoids Model the Mature In Vivo Synaptic Proteome
Neural organoids represent a promising approach for modelling neural circuits and neurological disease, yet their utility depends on whether they can recapitulate the molecular complexity of mature brain synapses. Here, we optimized a protocol to generate mature forebrain organoids from mouse embryonic stem cells and used time-resolved proteomics to define the emergence of synaptic proteins…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
