How Bladder Cells Fight Hidden E. coli: New Insights Into Recurrent UTIs
A new study finds the drug OM-89 may help bladder cells eliminate hidden E. coli by activating lysosomal pathways and increasing antibiotic uptake, potentially reducing bacterial regrowth in recurrent UTIs. The post How Bladder Cells Fight Hidden E. coli : New Insights Into Recurrent UTIs appeared first on GEN - Genetic Engineering and Biotechnology News .
Researchers have discovered that the drug OM-89 (Uro-Vaxom®) enhances the bladder cells' ability to eliminate intracellular E. coli, which is responsible for recurrent urinary tract infections (UTIs). The study, published in PLOS Pathogens, found that OM-89 activates cellular degradation pathways in bladder epithelial cells and increases antibiotic uptake.
The drug was shown to increase lysosomal acidification and enzyme activity, directly affecting the cells lining the bladder. By strengthening the bladder cells' ability to destroy hidden bacteria and helping antibiotics reach those bacteria, OM-89 reduces the regrowth of bacteria after treatment ends. This discovery suggests a host-directed approach to recurrent infection, reinforcing the scientific foundation supporting the use of Uro-Vaxom®.
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