AetherXeno: an allele-resolved receptor-occupancy atlas for regulatory pharmacogenomics
Motivation: Interpreting noncoding pharmacogenomic variants requires identifying the regulatory program that may be perturbed and the direction of the effect, information not supplied by population frequency or general regulatory annotations. Results: We developed AetherXeno, an allele-resolved atlas that scores all substitutions across 8,691 experimentally supported elements for PXR, FXR and AhR…
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