10 Best College Football Picks Against the Spread for Week 4

10. New Mexico vs. New Mexico State: The Lobos are the favored 11-point underdogs in this rivalry game. New Mexico State has a strong passing game and a better offense, but New Mexico has a better defense and has been successful in recent seasons. Possession time may be a deciding factor in this game.

8. and 9. Oklahoma State vs. West Virginia: The line is set at 61.5 total points with West Virginia as the 1.5-point underdogs. Oklahoma State has struggled on the road, but their defense is strong. West Virginia's offense could be the difference-maker, especially on their home field.

7. Texas vs. Tennessee: Texas is favored by 4.5 points against Tennessee. This is a closely contested game, but both teams have good offenses and defenses. Tennessee's pass rush could give them an edge, especially if they can pressure the Texas quarterback.

6. Oklahoma vs. Georgia: Oklahoma is the underdog by 44.5 points against Georgia. The Sooners have been inconsistent this season, but their defense has been strong. Georgia's offense has struggled at times, so the OU defense could hold them to under 23 points.

5. TCU vs. UCF: TCU is favored by 3.5 points against UCF. TCU has been playing well recently, and their offense should be able to control the clock. UCF's defense has been solid, but TCU's ground game should give them an advantage.

3. Iowa vs. Michigan: Iowa is the underdog by 38.5 points against Michigan. Both teams have decent offenses and defenses, but Iowa's offense has shown potential lately. Michigan's defense will be a challenge, but if Iowa can score consistently, they could cover the spread.

2. Ole Miss vs. Florida: Florida is favored by 58.5 points against Ole Miss. The Gators have been strong all season, and their offense and defense are both top-tier. Ole Miss has had some issues stopping top offenses, but this game is a toss-up.

1. Oregon vs. USC: Oregon is the heavy favorite by 61.5 points against USC. The Ducks have been dominant this season, and their offense is one of the best in the country. USC's defense has been inconsistent, but they are still a tough opponent. Expect a big win for Oregon.