Safer alternative for hormone replacement therapy during menopause proposed
When it comes to balancing hormonal changes during the transition to menopause, less can be more. Researchers at the University of São Paulo (USP) in Brazil demonstrated this when testing an alternative to conventional therapy. Rather than replacing estrogen, the team activated only one type of estrogen receptor in cells. This approach had broad metabolic benefits without stimulating the growth…
Researchers at the University of São Paulo (USP) in Brazil have developed a safer alternative to hormone replacement therapy during menopause. The innovative approach activated only one type of estrogen receptor, preventing the growth of reproductive tissues and metabolic issues. Conventional therapy replaces both estrogen and progesterone, but this targeted strategy focuses on estrogen receptor beta (ERβ), which does not increase the risk of hormone-sensitive tumors.
During menopause, a significant drop in estrogen disrupts metabolism, leading to increased visceral fat, insulin resistance, and cardiovascular risks. The new method restored fasting blood glucose levels, normalized lipid profiles, and reduced fat cell size without affecting the uterus. Additionally, it improved the liver's lipid metabolism by increasing fat oxidation, reducing bad cholesterol, and enhancing overall lipid profiles.
While it did not prevent weight gain, the therapy broadened metabolic health and liver function. Researchers aim to further explore this approach during the transition to menopause, seeking personalized treatment options for menopausal women.
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