MetaCarto: biologically faithful automatic layout for genome-scale metabolic maps

Motivation: Genome-scale metabolic models contain thousands of reactions, yet the pathway maps used to interpret them are still largely drawn by hand and cover only a small fraction of each model. Existing automatic layout methods mainly evaluate geometric appearance, such as edge crossings and spacing. However, a map can look clean while representing a reaction through the wrong metabolites,…

biorxiv.org ·1d ago

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