Intense Media Pressure an Emerging Challenge in CHO Business
Process intensification and the adoption of continuous-mode manufacturing has increased the consumption of culture media. Managing these ever-growing culture volumes in a cost and space efficient manner has become a major challenge for drug manufacturers, says Just – Evotec Biologics. The post Intense Media Pressure an Emerging Challenge in CHO Business appeared first on GEN - Genetic Engineering…
The production of protein therapeutics faces significant challenges, particularly with regard to storing and preparing culture media, according to Guy Rachmuth of Just – Evotec Biologics. He notes that manufacturers typically require tens to hundreds of thousands of liters of media, which necessitates robust storage solutions, including cold temperature preservation for many liquid media formulations.
Challenges increase in intensified production processes, where continuous perfusion of bioreactors necessitates higher volumes of cell culture media. To address these issues, Just – Evotec developed J.Media, a concentrated, room-temperature stable powder format. This innovation reduces storage footprint, simplifies logistics, and enhances manufacturing flexibility and efficiency. J.Media has been integrated into nearly 70 projects within the organization.
Rachmuth explains that J.Media has outperformed several commercial products in tests, demonstrating superior volumetric productivity and cumulative titer. The media maintains high cell viability at concentrations of 80-100 million cells/mL over 15-25 days or longer, and achieves volumetric productivities of up to 4-5 grams per liter per day in perfusion operations. This level of performance underscores the platform's capability to support highly efficient manufacturing processes.
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