Fluoxetine Hydrochloride Treatment Influences Site-Specific ADAR Editing and Transcriptome Regulation in Arid1b +/- Mice
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by repetitive behavior and impaired social interactions. Recent reports from human postmortem brain samples of ASD show transcriptome-wide dysregulations, including changes in differential gene expression and alternative splicing. An important mechanism regulating transcriptome function is the editing of double-stranded…
Fluoxetine hydrochloride treatment, a type of Selective Serotonin Reuptake Inhibitor (SSRI), alters site-specific editing rates in the double-stranded RNA of mice with a genetic mutation called Arid1b. This finding is relevant to Autism Spectrum Disorder (ASD) research, as ASD is characterized by transcriptome-wide dysregulations such as differential gene expression and alternative splicing.
The use of SSRIs can lead to changes in microRNA-mRNA interactions, which in turn can influence neurotransmission. The study of these editing rates in mice provides insight into potential mechanisms behind ASD pathology.
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