Deciphering Mechanistic Signatures in Drug-Drug Interactions with Dual Topology Graphs

Drug-drug interactions (DDIs) represent a critical challenge in drug development and clinical practice, as they can lead to severe adverse effects, including toxicity and reduced therapeutic efficacy. Deep learning methods have shown promise in large-scale, rapid DDI prediction; however, current approaches suffer from significant limitations in providing mechanistic insights into these…

biorxiv.org ·1d ago

We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.

Read the original at biorxiv.org →

More in Science

The wild turmeric that blooms quietly on Pitawala Patana

By Ifham Nizam On the windswept grasslands of Pitawala Patana, where visitors are naturally drawn to the dramatic sweep of the Knuckles mountains, the rocky outcrops and the distant silhouette of…

1d ago ·island.lk

Researchers Reconstruct Face of Oldest Known Homo sapiens

Scientists have created a digital facial approximation of the Jebel Irhoud hominin, whose remains are dated to about 315,000 years ago.

1d ago ·sci.news

Astrophysicists use wave simulations to open a new window on dark matter

Astrophysicists from The University of Hong Kong (HKU), working with a research team led by Beijing Normal University (BNU), have developed a more physically realistic approach to testing how…

1d ago ·phys.org

Crown-of-thorns starfish can help reefs thrive

Crown-of-thorns starfish (COTS) are infamous in the marine world. Their toxin-loaded thorns give them a menacing appearance, and they have a reputation as destroyers of coral reefs. New research from the University of Sydney challenges the perception of COTS as purely destructive.

1d ago ·phys.org

USM takes research beyond the lab

KUALA LUMPUR: Universiti Sains Malaysia (USM) has secured RM1.202 million in new industry funding from Intel Malaysia and Micron Memory Malaysia.

1d ago ·nst.com.my

Delaying cherry blossom to reduce frost damage

Climate change is causing many fruit trees to flower earlier, increasing their exposure to damaging late spring frosts. A study led by the University of Göttingen shows that the plant growth regulator ethephon can delay flowering in Kordia, a sweet cherry variety, potentially protecting blossoms and developing fruitlets from frost.

1d ago ·phys.org